Issue 4, 2024
From the journal:

Chemical Communications

A multi-cycle signal amplification-mediated single quantum dot nanosensor for PIWI-interacting RNA detection†

Qi-qin Ge,a   Qian Han,a   Yun Han,a   Fei Ma,*a   Chen-zhong Li*b  and  Chun-yang Zhang ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China
E-mail: fei@seu.edu.cn, zhangcy@seu.edu.cn

b Biomedical Engineering, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China
E-mail: lichenzhong@cuhk.edu.cn

Abstract

We construct a single quantum dot-based nanosensor for piRNA detection based on ligation-mediated multi-cycle signal amplification. This nanosensor is homogenous, selective, and sensitive with a detection limit of 0.104 fM. Moreover, it can detect the endogenous piRNA level in different cell lines, and discriminate cancer tissues from normal tissues.

Graphical abstract: A multi-cycle signal amplification-mediated single quantum dot nanosensor for PIWI-interacting RNA detection

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Article information

DOI
https://doi.org/10.1039/D3CC05639B
Article type
Communication
Submitted
16 Nov 2023
Accepted
06 Dec 2023
First published
06 Dec 2023

Chem. Commun., 2024,60, 408-411

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A multi-cycle signal amplification-mediated single quantum dot nanosensor for PIWI-interacting RNA detection

Q. Ge, Q. Han, Y. Han, F. Ma, C. Li and C. Zhang, Chem. Commun., 2024, 60, 408 DOI: 10.1039/D3CC05639B

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