Issue 1, 2024

BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

Abstract

Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood–brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood–brain barrier.

Graphical abstract: BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

Supplementary files

Article information

Article type
Communication
Submitted
08 Oct 2023
Accepted
25 Nov 2023
First published
11 Dec 2023
This article is Open Access
Creative Commons BY license

RSC Chem. Biol., 2024,5, 7-11

BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

M. C. Lucana, R. Lucchi, F. Gosselet, C. Díaz-Perlas and B. Oller-Salvia, RSC Chem. Biol., 2024, 5, 7 DOI: 10.1039/D3CB00194F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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