Issue 17, 2024

Reactive oxygen species driven prodrug-based nanoscale carriers for transformative therapies

Abstract

Reactive oxygen species (ROS) drive processes in various pathological conditions serving as an attractive target for therapeutic strategies. This review highlights the development and use of ROS-dependent prodrug-based nanoscale carriers that has transformed many biomedical applications. Incorporating prodrugs into nanoscale carriers not only improves their stability and solubility but also enables site-specific drug delivery ultimately enhancing the therapeutic effectiveness of the nanoscale carriers. We critically examine recent advances in ROS-responsive nanoparticulate platforms, encompassing liposomes, polymeric nanoparticles, and inorganic nanocarriers. These platforms facilitate precise control over drug release upon encountering elevated ROS levels at disease sites, thereby minimizing off-target effects and maximizing therapeutic efficiency. Furthermore, we investigate the potential of combination therapies in which ROS-activated prodrugs are combined with other therapeutic agents and underscore their synergistic potential for treating multifaceted diseases. This comprehensive review highlights the immense potential of ROS-dependent prodrug-based nanoparticulate systems in revolutionizing biomedical applications; such nanoparticulate systems can facilitate selective and controlled drug delivery, reduce toxicity, and improve therapeutic outcomes for ROS-associated diseases.

Graphical abstract: Reactive oxygen species driven prodrug-based nanoscale carriers for transformative therapies

Article information

Article type
Review Article
Submitted
09 May 2024
Accepted
13 Jul 2024
First published
23 Jul 2024

Biomater. Sci., 2024,12, 4335-4353

Reactive oxygen species driven prodrug-based nanoscale carriers for transformative therapies

S. Vasvani, A. Vasukutty, R. Bardhan, I. Park and S. Uthaman, Biomater. Sci., 2024, 12, 4335 DOI: 10.1039/D4BM00647J

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