Issue 2, 2024

Drug delivery nanoparticles for preventing implant bacterial infections based on the bacteria and immunity mechanisms

Abstract

Implant dysfunction and failure during medical treatment can be attributed to bacterial infection with Staphylococcus aureus and Enterococcus faecalis, which are the prevalent strains responsible for implant infections. Currently, antibiotics are primarily used either locally or systemically to prevent and treat bacterial infections in implants. However, the effectiveness of this approach is unsatisfactory. Therefore, the development of new antimicrobial medications is crucial to address the clinical challenges associated with implant infections. In this study, a nanoparticle (ICG+RSG) composed of indocyanine green (ICG) and rosiglitazone (RSG), and delivered using 1,2-dipalmitoyl-snglycero-3-phosphocholine (DPPC) was prepared. ICG+RSG has photothermal and photodynamic properties to eliminate bacteria at the infection site by releasing reactive oxygen species and increasing the temperature. Additionally, it regulates phagocytosis and macrophage polarization to modulate the immune response in the body. ICG+RSG kills bacteria and reduces tissue inflammation, showing potential for preventing implant infections.

Graphical abstract: Drug delivery nanoparticles for preventing implant bacterial infections based on the bacteria and immunity mechanisms

Supplementary files

Article information

Article type
Paper
Submitted
28 Sep 2023
Accepted
14 Nov 2023
First published
21 Nov 2023

Biomater. Sci., 2024,12, 413-424

Drug delivery nanoparticles for preventing implant bacterial infections based on the bacteria and immunity mechanisms

C. Chen, Q. Xiao, L. Xiao, M. Feng, F. Liu, K. Yao, Y. Cui, T. Zhang and Y. Zhang, Biomater. Sci., 2024, 12, 413 DOI: 10.1039/D3BM01584J

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