Issue 18, 2024

Tailoring of bioactive glass and glass-ceramics properties for in vitro and in vivo response optimization: a review

Abstract

Bioactive glasses are inorganic biocompatible materials that can find applications in many biomedical fields. The main application is bone and dental tissue engineering. However, some applications in contact with soft tissues are emerging. It is well known that both bulk (such as composition) and surface properties (such as morphology and wettability) of an implanted material influence the response of cells in contact with the implant. This review aims to elucidate and compare the main strategies that are employed to modulate cell behavior in contact with bioactive glasses. The first part of this review is focused on the doping of bioactive glasses with ions and drugs, which can be incorporated into the bioceramic to impart several therapeutic properties, such as osteogenic, proangiogenic, or/and antibacterial ones. The second part of this review is devoted to the chemical functionalization of bioactive glasses using drugs, extra-cellular matrix proteins, vitamins, and polyphenols. In the third and final part, the physical modifications of the surfaces of bioactive glasses are reviewed. Both top-down (removing materials from the surface, for example using laser treatment and etching strategies) and bottom-up (depositing materials on the surface, for example through the deposition of coatings) strategies are discussed.

Graphical abstract: Tailoring of bioactive glass and glass-ceramics properties for in vitro and in vivo response optimization: a review

Article information

Article type
Review Article
Submitted
26 Sep 2023
Accepted
05 Mar 2024
First published
06 Aug 2024
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2024,12, 4546-4589

Tailoring of bioactive glass and glass-ceramics properties for in vitro and in vivo response optimization: a review

E. Piatti, M. Miola and E. Verné, Biomater. Sci., 2024, 12, 4546 DOI: 10.1039/D3BM01574B

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