Issue 37, 2024

Glowing discoveries: Schiff base-cyanostilbene probes illuminating metal ions and biological entities

Abstract

Schiff bases featuring cyanostilbene units have emerged as versatile and highly effective probes for the selective detection of various metal ions as well as biologically important species. This review comprehensively highlights recent advances in the development and application of the probes, which exhibit remarkable Aggregation-Induced Emission (AIE), Twisted Intramolecular Charge Transfer (TICT), and Excited-State Intramolecular Proton Transfer (ESIPT) properties. These unique structural characteristics facilitate their potential applications in the detection of biologically important metal ions such as Zn2+, Fe3+, Cu2+, Hg2+ and Co2+ ions with high sensitivity and selectivity. Furthermore, these probes have demonstrated significant potential in the recognition of vital biological species, including arginine, hydrazine and hypochlorite (ClO). The present review discusses the underlying detection mechanisms, emphasizing the role of the Schiff base and cyanostilbene moieties for the selective detection of particular biologically important entities. Moreover, this discussion highlights the practical applications, problems, and future directions in this fast-growing field, emphasizing the vital importance of these probes in both analytical chemistry and bioassays.

Graphical abstract: Glowing discoveries: Schiff base-cyanostilbene probes illuminating metal ions and biological entities

Article information

Article type
Tutorial Review
Submitted
03 Jul 2024
Accepted
10 Aug 2024
First published
12 Aug 2024
This article is Open Access
Creative Commons BY-NC license

Anal. Methods, 2024,16, 6323-6336

Glowing discoveries: Schiff base-cyanostilbene probes illuminating metal ions and biological entities

A. A, C. A. Swamy P and A. Rose, Anal. Methods, 2024, 16, 6323 DOI: 10.1039/D4AY01242A

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