Issue 39, 2024

Peptides in the detection of metal ions

Abstract

By means of their specific interactions with different metal ions, naturally occurring proteins control structures and functions of many biological processes and functions in organisms. In view of natural metallopeptides, scientists have proposed artificial peptides which coordinate with metal ions through their functional groups either for introducing a special reactivity or for constructing various sensors. However, the design of new peptide ligands requires a deep understanding of the structures, assembly properties, and dynamic behaviors of such peptides. This review briefly describes detection strategies of metal ions via coordination to the binding sites in peptides. The principles and functions of sensing systems are described as well. We also highlight some examples of a metal-induced peptide self-assembly with relevance to biotechnology applications.

Graphical abstract: Peptides in the detection of metal ions

Article information

Article type
Minireview
Submitted
02 Jul 2024
Accepted
02 Sep 2024
First published
04 Sep 2024

Anal. Methods, 2024,16, 6589-6598

Peptides in the detection of metal ions

X. Li, X. Zhou and J. Hu, Anal. Methods, 2024, 16, 6589 DOI: 10.1039/D4AY01232A

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