Chelation therapy-inspired design of a water-stable fluorescent probe for the effectual monitoring of copper(ii) ions in real water

Abstract

This work introduces a thought-provoking design to develop a water-soluble chemical probe, sodium 4-hydroxy-3-((E)-((E)-((2-hydroxynaphthalen-1yl)methylene)hydrazono)methyl) benzenesulfonate (SW2) and its analytical characterization for the efficient detection and monitoring of Cu2+ ions in a matrix of s-, d-, and f-metal ions in pure water. The water-stable molecular probe, SW2, in the presence of Cu2+ salts in pure water exhibits a fluorescence turn-off characteristic with a high detection limit, 3.8 μM, and irresistibly holds 4-cycle reversibility in the presence of sulphide ions without any significant loss of its chemosensing efficiency. Spectroscopic and computational studies ensure 1 : 1 complexation between SW2 and Cu2+ ions, leading to the formation of SW2–Cu2+ chelate, thus inducing dynamic quenching of SW2 emission, which subsequently reverts on the addition of S2− ions in water. Additionally, the SW2–Cu2+ chelate was isolated in microcrystalline powder and the complexation was studied with mass spectrometry and EPR analysis. Computational analysis reveals the remarkable reduction in the S0–S1 energy level of the SW2–Cu2+ complex, which is attributed to the drastic quenching of the fluorescence intensity. Furthermore, SW2 was successfully applied to the detection of Cu2+ ions in tap and pond water. Interestingly, the probe is also effective for the determination of Cu2+ ions in the aqueous solution of a Cu-based fungicide (copper oxychloride), commercially available as Blitox in India, thus evaluating the effectiveness of SW2 in real sample analysis.

Graphical abstract: Chelation therapy-inspired design of a water-stable fluorescent probe for the effectual monitoring of copper(ii) ions in real water

Supplementary files

Article information

Article type
Paper
Submitted
01 May 2024
Accepted
21 Jun 2024
First published
24 Jun 2024

Anal. Methods, 2024, Advance Article

Chelation therapy-inspired design of a water-stable fluorescent probe for the effectual monitoring of copper(II) ions in real water

S. Roy, P. Choudhury and B. Biswas, Anal. Methods, 2024, Advance Article , DOI: 10.1039/D4AY00808A

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