Issue 30, 2023

Restriction of intramolecular bending (RIB) enables the quantitative design of AIEgens

Abstract

Fluorescent compounds with aggregation-induced emission (AIE) characteristics (or AIEgens) have garnered significant research interest for various applications. The establishment of new AIE mechanisms coupled with quantitative prediction power is crucial to accelerate the development of novel AIE materials. Herein, we report the discovery of a new AIE mechanism, known as restriction of intramolecular bending (RIB), using computational chemistry and experimental validation. In RIB, the structural bending of the fluorophore scaffold caused by steric effects leads to fluorescence quenching in a dilute solution; fluorescence is only recovered in the aggregate state when the bending is inhibited. This RIB mechanism affords a practical guide for the quantitative molecular design of AIEgens, i.e., by converting traditional aggregation-caused quenching (ACQ) fluorophores to AIEgens through simple structural modifications. We believe that the introduction of the RIB mechanism paves a new avenue for the rational development of functional AIEgens.

Graphical abstract: Restriction of intramolecular bending (RIB) enables the quantitative design of AIEgens

Supplementary files

Article information

Article type
Paper
Submitted
27 Apr 2023
Accepted
04 Jun 2023
First published
06 Jun 2023

J. Mater. Chem. C, 2023,11, 10205-10214

Restriction of intramolecular bending (RIB) enables the quantitative design of AIEgens

W. Chi, J. Dai, C. Yan, D. Tan, Z. Guo and X. Liu, J. Mater. Chem. C, 2023, 11, 10205 DOI: 10.1039/D3TC01481A

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