Issue 45, 2023

Recent advances and prospects in nanomaterials for bacterial sepsis management

Abstract

Bacterial sepsis is a life-threatening condition caused by bacteria entering the bloodstream and triggering an immune response, underscoring the importance of early recognition and prompt treatment. Nanomedicine holds promise for addressing sepsis through improved diagnostics, nanoparticle biosensors for detection and imaging, enhanced antibiotic delivery, combating resistance, and immune modulation. However, challenges remain in ensuring safety, regulatory compliance, scalability, and cost-effectiveness before clinical implementation. Further research is needed to optimize design, efficacy, safety, and regulatory strategies for effective utilization of nanomedicines in bacterial sepsis diagnosis and treatment. This review highlights the significant potential of nanomedicines, including improved drug delivery, enhanced diagnostics, and immunomodulation for bacterial sepsis. It also emphasizes the need for further research to optimize design, efficacy, safety profiles, and address regulatory challenges to facilitate clinical translation.

Graphical abstract: Recent advances and prospects in nanomaterials for bacterial sepsis management

Article information

Article type
Review Article
Submitted
23 Sep 2023
Accepted
22 Oct 2023
First published
25 Oct 2023
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2023,11, 10778-10792

Recent advances and prospects in nanomaterials for bacterial sepsis management

C. Zhou, Y. Liu, Y. Li and L. Shi, J. Mater. Chem. B, 2023, 11, 10778 DOI: 10.1039/D3TB02220J

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