Issue 38, 2023

Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs

Abstract

Although Metal–organic frameworks (MOFs) have received attention as drug delivery systems, their application in the delivery of macromolecules is limited by their pore size and opening. Herein, we present the synthesis of nanostructured MUV-2, a hierarchical mesoporous iron-based MOF that can store high payloads of the macromolecular drug paclitaxel (ca. 23% w/w), increasing its selectivity towards HeLa cancer cells over HEK non-cancerous cells. Moreover, this NanoMUV-2 permits full degradation under simulated physiological conditions while maintaining biocompatibility, and is amenable to specific surface modifications that increase its cell permeation, efficient cytosol delivery and cancer-targeting effect, further intensifying the cancer selectivity of paclitaxel.

Graphical abstract: Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs

Supplementary files

Article information

Article type
Paper
Submitted
11 Aug 2023
Accepted
08 Sep 2023
First published
11 Sep 2023
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2023,11, 9179-9184

Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs

I. Abánades Lázaro, M. Vicent-Morales, G. Mínguez Espallargas and M. Giménez-Marqués, J. Mater. Chem. B, 2023, 11, 9179 DOI: 10.1039/D3TB01819A

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