Issue 35, 2023

Transdermal drug delivery via microneedles for musculoskeletal systems

Abstract

As the population is ageing and lifestyle is changing, the prevalence of musculoskeletal (MSK) disorders is gradually increasing with each passing year, posing a serious threat to the health and quality of the public, especially the elderly. However, currently prevalent treatments for MSK disorders, mainly administered orally and by injection, are not targeted to the specific lesion, resulting in low efficacy along with a series of local and systemic adverse effects. Microneedle (MN) patches loaded with micron-sized needle array, combining the advantages of oral administration and local injection, have become a potentially novel strategy for the administration and treatment of MSK diseases. In this review, we briefly introduce the basics of MNs and focus on the main characteristics of the MSK systems and various types of MN-based transdermal drug delivery (TDD) systems. We emphasize the progress and broad applications of MN-based transdermal drug delivery (TDD) for MSK systems, including osteoporosis, nutritional rickets and some other typical types of arthritis and muscular damage, and in closing summarize the future prospects and challenges of MNs application.

Graphical abstract: Transdermal drug delivery via microneedles for musculoskeletal systems

Article information

Article type
Review Article
Submitted
25 Jun 2023
Accepted
17 Jul 2023
First published
19 Jul 2023

J. Mater. Chem. B, 2023,11, 8327-8346

Transdermal drug delivery via microneedles for musculoskeletal systems

H. Zheng, X. Xie, H. Ling, X. You, S. Liang, R. Lin, R. Qiu and H. Hou, J. Mater. Chem. B, 2023, 11, 8327 DOI: 10.1039/D3TB01441J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements