Issue 36, 2023

Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that causes memory and cognitive dysfunction and reduces a person's decision-making and reasoning functions. AD is the leading cause of dementia in the elderly. Patients with AD have increased expression of pro-inflammatory cytokines in the nervous system, and the sustained inflammatory response impairs neuronal function. Meanwhile, long-term use of anti-inflammatory drugs can reduce the incidence of AD to some extent. This confirms that anti-neuroinflammation may be an effective treatment for AD. Gold nanoparticles (AuNPs) are an emerging nanomaterial with promising physicochemical properties, anti-inflammatory and antioxidant. AuNPs reduce neuroinflammation by inducing macrophage polarization toward the M2 phenotype, reducing pro-inflammatory cytokine expression, blocking leukocyte adhesion, and decreasing oxidative stress. Therefore, AuNPs are gradually attracting the interest of scholars and are used for treating inflammatory diseases and drug delivery. Herein, we explored the role and mechanism of AuNPs in treating neuroinflammation in AD. The use of AuNPs for treating AD is a topic worth exploring in the future, not only to help solve a global public health problem but also to provide a reference for treating other neuroinflammatory diseases.

Graphical abstract: Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease

Article information

Article type
Review Article
Submitted
05 May 2023
Accepted
20 Aug 2023
First published
21 Aug 2023
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2023,11, 8605-8621

Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease

M. Aili, K. Zhou, J. Zhan, H. Zheng and F. Luo, J. Mater. Chem. B, 2023, 11, 8605 DOI: 10.1039/D3TB01023F

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