Issue 29, 2023

Integrated osteoimmunomodulatory strategies based on designing scaffold surface properties in bone regeneration

Abstract

Those who have used traditional biomaterials as bone substitutes have always regarded the immune response as an obstacle leading to implant failure. However, cumulative evidence revealed that blindly minimizing host immune reactions cannot induce successful bone regeneration. With the emergence of the new concept of osteoimmunology, the intimate mutual effects between the skeletal system and the immune system have been gradually recognized, promoting the innovation of biomaterials with osteoimmunomodulatory properties. By tuning the surface properties, biomaterials can precisely manipulate the osteoimmune environment favoring bone regeneration. In this review, we first reviewed the mutual effects between the skeletal system and the immune system to show the importance of immunomodulation on bone regeneration. Subsequently, we summarize the recent developments in surface modification strategies in terms of the surface physicochemical properties and surface coatings and explain how these modification strategies work.

Graphical abstract: Integrated osteoimmunomodulatory strategies based on designing scaffold surface properties in bone regeneration

Article information

Article type
Review Article
Submitted
03 Apr 2023
Accepted
01 Jun 2023
First published
05 Jun 2023

J. Mater. Chem. B, 2023,11, 6718-6745

Integrated osteoimmunomodulatory strategies based on designing scaffold surface properties in bone regeneration

Z. Chen, F. Xing, Y. Zhou, P. Yu, J. Xu, R. Luo, C. Zhou, Z. Xiang, P. M. Rommens, M. Liu and U. Ritz, J. Mater. Chem. B, 2023, 11, 6718 DOI: 10.1039/D3TB00727H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements