Issue 23, 2023

Rod-to-sphere elemental reconstruction of biocompatible Ag2Te–Ag4.53–Te3 nanoparticles for triple negative breast cancer photo-nano-therapy

Abstract

Silver nanoparticles (AgNPs) continue to be applied to agricultural and medical applications because of their antibacterial and antifungal effects. However, AgNPs are vulnerable to poisoning by oxidation or sulfidation, and unintentional toxicity can occur via leaching. Therefore, ensuring the stability of AgNPs for practical applications is considered an important requirement. In this study, we propose the solvothermal galvanic replacement of a Te nanorod (TeNR) template with a Ag precursor to manufacture highly stable and biocompatible Ag–Te nanoparticles (AgTeNPs). In addition to their high stability, AgTeNPs composed of Ag2Te–Ag4.53Te3 were evaluated as a nanotherapeutic agent enabled by their selective toxicity through metabolic degradation in breast cancer cells. It has been demonstrated that combinatorial treatment with hyperthermic cancer-cell ablation through photothermal conversion provides an effective cancer treatment in vitro and in vivo. The discovered new biocompatible Ag nanomaterials with innate anticancer effects are expected to be applied to various application fields.

Graphical abstract: Rod-to-sphere elemental reconstruction of biocompatible Ag2Te–Ag4.53–Te3 nanoparticles for triple negative breast cancer photo-nano-therapy

Supplementary files

Article information

Article type
Paper
Submitted
12 Feb 2023
Accepted
12 May 2023
First published
13 May 2023

J. Mater. Chem. B, 2023,11, 5142-5150

Rod-to-sphere elemental reconstruction of biocompatible Ag2Te–Ag4.53–Te3 nanoparticles for triple negative breast cancer photo-nano-therapy

H. Ahn, S. Kang, K. Kang, D. N. Lee, D. Min and H. Jang, J. Mater. Chem. B, 2023, 11, 5142 DOI: 10.1039/D3TB00297G

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