Dual-stimuli responsive skin–core structural fibers with an in situ crosslinked alginate ester for hydrophobic drug delivery

Abstract

To solve the problems of low bioavailability and low intestinal release efficiency of curcumin as a hydrophobic drug in the treatment of diabetes, a novel alginate ester/Antarctic krill protein/2-formylphenylboronic acid (AE/AKP/2-FPBA) skin–core structural fiber with pH and glucose stimulation responsiveness was prepared by an acid-catalyzed polyol in situ crosslinked phase separation method as a drug delivery system. The reaction mechanism and apparent morphology of the fiber were studied. The controlled release ability of the fiber in simulated liquids was evaluated. AE targeted the release of curcumin by pH stimulation; the release amount in the simulated colonic fluid reached 100%, while the release amount in the simulated digestive fluid was less than 12%. 2-FPBA controlled the release rate of curcumin by glucose stimulation, which increases with the increase of 2-FPBA content. Moreover, the cytotoxicity test confirmed that the skin–core structural fiber was non-toxic. These results suggest that skin–core structural fibers have great potential as curcumin delivery systems.