Issue 9, 2023

Carbon monoxide therapy: a promising strategy for cancer

Abstract

Cancer is one of the acute life-threatening diseases endangering the whole of humanity. The treatment modalities for cancer are various. However, in most cases, a single treatment choice provides multiple side effects, poor targeting, and ineffective treatment. In recent years, the physiological regulatory function of carbon monoxide (CO) in the cancer process has been reported gradually, and CO-related nano-drugs have been explored. It shows better application prospects in cancer treatment and provides new ideas for treatment. The present review introduces the pathophysiological role of CO. The recent advances in cancer therapy, such as CO-mediated gas therapy, combined application of CO chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT), and immunotherapy, are described. Current challenges and future developments in CO-based treatment are also discussed. This review provides comprehensive information on recent advances in CO therapy and also some valuable guidance for promoting the progress of gas therapy nanomedicine.

Graphical abstract: Carbon monoxide therapy: a promising strategy for cancer

Article information

Article type
Review Article
Submitted
29 Nov 2022
Accepted
28 Jan 2023
First published
31 Jan 2023

J. Mater. Chem. B, 2023,11, 1849-1865

Carbon monoxide therapy: a promising strategy for cancer

J. Chai, J. Zhu, Y. Tian, K. Yang, J. Luan and Y. Wang, J. Mater. Chem. B, 2023, 11, 1849 DOI: 10.1039/D2TB02599J

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