Issue 8, 2023

Multifunctional and multimodality theranostic nanomedicine for enhanced phototherapy

Abstract

Photodynamic therapy (PDT) has attracted much attention in recent years for its favorable therapeutic efficacy in cancer therapy. However, PDT alone is insufficient to improve the therapeutic efficiency mainly due to the limited penetration depth of light, the insufficient O2 supply in the hypoxic microenvironment, and the high level of reducing substances in cancer cells. To overcome these limitations, a multifunctional MnO2 nanoparticle was constructed with honeycomb MnO2 which was loaded with the photosensitizer Ce6 and modified with polydopamine on its surface (HMnO2/C&P) to achieve efficient PDT/mild photothermal treatment (PTT) combination therapy. HMnO2/C&P had high drug loading contents (11.2% Ce6) and can be responsive to the tumor microenvironment (TME), supply O2 to alleviate the hypoxic microenvironment, and clear GSH to reduce the consumption of ROS, thus enhancing the PDT effect. The introduction of PDA can improve the stability of HMnO2/C&P, and further give the ability of PTT to act as nanomedicine. The results of in vitro and in vivo experiments show that HMnO2/C&P based PDT/mild PTT combination therapy has an excellent inhibitory effect on tumor growth. Meanwhile, HMnO2/C&P can act as a fluorescence imaging reagent and a TME triggerable magnetic resonance imaging (MRI) contrast agent, thus having excellent multimodal self-tracking abilities. Collectively, this study provides a new perspective on the design of multifunctional theranostic nanomedicine to maximize the efficacy of cancer phototherapy.

Graphical abstract: Multifunctional and multimodality theranostic nanomedicine for enhanced phototherapy

Supplementary files

Article information

Article type
Paper
Submitted
28 Oct 2022
Accepted
12 Jan 2023
First published
12 Jan 2023

J. Mater. Chem. B, 2023,11, 1808-1817

Multifunctional and multimodality theranostic nanomedicine for enhanced phototherapy

L. Yan, S. Lin, L. Wang, Y. Wang, D. Zhou and Q. Zeng, J. Mater. Chem. B, 2023, 11, 1808 DOI: 10.1039/D2TB02345H

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