Volume 2, 2023

Polymersome-based ion-selective nano-optodes containing ionophores

Abstract

Nanoscale ion-selective optodes (nano-ISOs) are versatile optical ion sensing tools with ionophores, ion exchangers, optical signal transducers, and sometimes plasticizers. Nano-ISOs were previously developed based on various nanoparticles with a topological solid core to contain the active sensing components. In this work, polymersomes, with a topologically hollow structure, were utilized as the matrix of nano-ISOs. Ca2+-selective polymersomes with high selectivity and a sub-micromolar detection limit were developed with a calcium ionophore and successfully used to determine the total calcium concentration in diluted human serum. With a sodium ionophore, Na+-selective polymersomes were also obtained, indicating that ionophore-based polymersomes are promising in forming a general ion-selective optical sensing platform.

Graphical abstract: Polymersome-based ion-selective nano-optodes containing ionophores

Supplementary files

Article information

Article type
Paper
Submitted
02 Jun 2023
Accepted
07 Jul 2023
First published
10 Jul 2023
This article is Open Access
Creative Commons BY-NC license

Sens. Diagn., 2023,2, 1286-1291

Polymersome-based ion-selective nano-optodes containing ionophores

Y. Cui, J. Zhai, Y. Wang and X. Xie, Sens. Diagn., 2023, 2, 1286 DOI: 10.1039/D3SD00133D

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