Design and development of a fluorometric and colorimetric sensor for toxic cyanide detection by pyridinium scaffolds: live cell imaging and real sample analysis

Abstract

Polyheteroaryl pyridinium-based indenophenanthridine is synthesized using the conventional method. The synthesized pyridinium core indenophenanthridine detects cyanide ion (CN⁻) in a ratiometric manner with an excellent detection limit (1.2 nM). The CN⁻ sensing ability of the probe was treated for practical applications in food extracts, water samples, and U87 cell lines. The probe successfully detected the CN⁻ anion in real samples and cell lines.