Issue 50, 2023, Issue in Progress
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RSC Advances

A domino reaction for the synthesis of pyrrolo[2,1-a]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions†

Zheng Luo,ab   Huayou Hu, ORCID logo *a   Chao Wang,b   Zhen Yang ORCID logo cd  and  Yefei Wangcd  

* Corresponding authors

a Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, P. R. China
E-mail: HuayouHu@HYTC.EDU.CN

b School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, P. R. China

c Key Laboratory of Unconventional Oil & Gas Development, China University of Petroleum (East China), Qingdao 266580, P. R. China

d Shandong Key Laboratory of Oilfield Chemistry, School of Petroleum Engineering, China University of Petroleum (East China), Qingdao 266580, P. R. China

Abstract

Pyrrolo[2,1-a]isoquinoline derivatives were synthesized from 2-aryl-pyrrolidines and alkynes via an oxidative dehydrogenation/cyclization coupling/dehydrogenative aromatization domino process. This reaction was promoted by a four-component catalytic system which included [RuCl2(p-cymene)]2, CuCl, copper acetate monohydrate and TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) under aerobic conditions.

Graphical abstract: A domino reaction for the synthesis of pyrrolo[2,1-a]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions

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Article information

DOI
https://doi.org/10.1039/D3RA07653A
Article type
Paper
Submitted
09 Nov 2023
Accepted
30 Nov 2023
First published
06 Dec 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 35617-35620

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A domino reaction for the synthesis of pyrrolo[2,1-a]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions

Z. Luo, H. Hu, C. Wang, Z. Yang and Y. Wang, RSC Adv., 2023, 13, 35617 DOI: 10.1039/D3RA07653A

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