Issue 43, 2023, Issue in Progress
From the journal:

RSC Advances

A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism†

Aude Blanchard,a   Mikhail Abramov,b   Camille Hassan,a   Philippe Marlière,cd   Piet Herdewijn ORCID logo b  and  Valérie Pezo ORCID logo *a  

* Corresponding authors

a Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, 2 Rue Gaston Crémieux, 91057 Evry, France
E-mail: vpezo@genoscope.cns.fr

b Laboratory for Medicinal Chemistry, Rega Institute, Herestraat 49, KU Leuven, Leuven, Belgium

c Theraxen SA, 296 route de Longwy, Luxembourg

d TESSSI, 81 Rue Réaumur, Paris 75002, France

Abstract

We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an Escherichia coli strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the propagation of non-natural genetic information or the selection of potential drugs.

Graphical abstract: A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism

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Article information

DOI
https://doi.org/10.1039/D3RA06172H
Article type
Paper
Submitted
11 Sep 2023
Accepted
04 Oct 2023
First published
12 Oct 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 29862-29865

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A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism

A. Blanchard, M. Abramov, C. Hassan, P. Marlière, P. Herdewijn and V. Pezo, RSC Adv., 2023, 13, 29862 DOI: 10.1039/D3RA06172H

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