Issue 41, 2023, Issue in Progress

Past-expiration-date liquid disinfectants to deactivate biological and chemical toxins on building material surfaces

Abstract

In this study, we evaluated the deactivating efficacy of strong basicity-based (T4-102) and hydrogen peroxide-based (DF-200) disinfectants that were past their expiration date when used to deactivate biological and chemical toxins on building material surfaces. The decontamination efficacies of DF-200 and T4-102 disinfectants against dimethyl methylphosphonate (DMMP) and 2-chloroethyl ethylsulfide (2-CEES) were studied using GC-MS analysis. The bactericidal efficacies of disinfectants against Gram-negative E. coli and P. aeruginosa, and Gram-positive B. subtilis and S. aureus, were assessed in terms of the zone of inhibition, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). The results indicated that the deactivation efficacy varied significantly according to the disinfectant amount, contact time, and building material. Higher efficacy of up to 99–100% was observed for biological toxins, despite passing their expiration dates. Approximately 70–78% of deactivation efficacies were observed for disinfectants against DMMP on the tile coupon at 100 μL and 24 h contact time. Moreover, the deactivation efficacy of DF-200 was better than that of T4-102. The data presented here demonstrate that the responders may use past-expiration-date disinfectants for efficacious disinfectaion in large-scale contamination incidents.

Graphical abstract: Past-expiration-date liquid disinfectants to deactivate biological and chemical toxins on building material surfaces

Article information

Article type
Paper
Submitted
23 Jul 2023
Accepted
19 Sep 2023
First published
03 Oct 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 28904-28911

Past-expiration-date liquid disinfectants to deactivate biological and chemical toxins on building material surfaces

J. Wang, W. Huang, K. Cheng, N. Liu and K. Wu, RSC Adv., 2023, 13, 28904 DOI: 10.1039/D3RA04965E

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