Issue 43, 2023, Issue in Progress

An amplified electrochemical sensor employing one-step synthesized nickel–copper–zinc ferrite/carboxymethyl cellulose/graphene oxide nanosheets composite for sensitive analysis of omeprazole

Abstract

In this work, a signal amplification strategy was designed by the fabrication of a highly sensitive and selective electrochemical sensor based on nickel–copper–zinc ferrite (Ni0.4Cu0.2Zn0.4Fe2O4)/carboxymethyl cellulose (CMC)/graphene oxide nanosheets (GONs) composite modified glassy carbon electrode (GCE) for determination of omeprazole (OMP). The one-step synthesized Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs nanocomposite was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy and X-ray diffraction techniques. Then, the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE was applied to study the electrochemical behavior of the OMP. Electrochemical data show that the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE exhibits superior electrocatalytic performance on the oxidation of OMP compared with bare GCE, GONs/GCE, CMC/GONs/GCE and MFe2O4/GCE (M = Cu, Ni and Zn including single, double and triple of metals) which can be attributed to the synergistic effects of the nanocomposite components, outstanding electrical properties of Ni0.4Cu0.2Zn0.4Fe2O4 and high conductivity of CMC/GONs as well as the further electron transport action of the nanocomposite. Under optimal conditions, the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE offers a high performance toward the electrodetermination of OMP with the wide linear-range responses (0.24–5 and 5–75 μM), lower detection limit (0.22 ± 0.05 μM), high sensitivity (1.1543 μA μM−1 cm−2), long-term signal stability and reproducibility (RSD = 2.54%). It should be noted that the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE sensor could also be used for determination of OMP in drug and biological samples, indicating its feasibility for real analysis.

Graphical abstract: An amplified electrochemical sensor employing one-step synthesized nickel–copper–zinc ferrite/carboxymethyl cellulose/graphene oxide nanosheets composite for sensitive analysis of omeprazole

Supplementary files

Article information

Article type
Paper
Submitted
15 Jul 2023
Accepted
03 Oct 2023
First published
18 Oct 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 29931-29943

An amplified electrochemical sensor employing one-step synthesized nickel–copper–zinc ferrite/carboxymethyl cellulose/graphene oxide nanosheets composite for sensitive analysis of omeprazole

B. Habibi, S. Pashazadeh, A. Pashazadeh and L. A. Saghatforoush, RSC Adv., 2023, 13, 29931 DOI: 10.1039/D3RA04766K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements