One-pot, three-component, iron-catalyzed synthesis of benzimidazoles via domino C–N bond formation

Abstract

An efficient one-pot, three-component process for the synthesis of benzimidazole derivatives using a catalytic amount of Fe(III) porphyrin has been developed. The reaction proceeds via domino C–N bond formation and cyclization reactions of benzo-1,2-quinone, aldehydes and ammonium acetate as a nitrogen source to selectively produce benzimidazole. A number of benzimidazole derivatives have been synthesized using this method in high yields under mild reaction conditions.