Issue 37, 2023

Development of a novel near-infrared molecule rotator for early diagnosis and visualization of viscosity changes in acute liver injury models

Abstract

Acute liver injury leading to acute liver failure can be a life-threatening condition. Therefore, timely and accurate early diagnosis of the onset of acute liver injury in vivo is critical. Viscosity is one of the key parameters that can accurately reflect the levels of relevant active analytes at the cellular level. Herein, a novel near-infrared molecule rotator, DJM, was designed and synthesized. This probe exhibited a highly sensitive (461-fold from PBS solution to 95% glycerol solution) and selective response to viscosity with a maximum emission wavelength of 760 nm and a Stokes shift of 240 nm. Furthermore, DJM has exhibited a remarkable capacity to discern viscosity changes induced by nystatin in viable cells with sensitivity and selectivity and further applied in the zebrafish and mouse model of acute liver injury. Additionally, DJM may potentially offer direction for the timely observation and visualization of viscosity in more relevant disease models in the future.

Graphical abstract: Development of a novel near-infrared molecule rotator for early diagnosis and visualization of viscosity changes in acute liver injury models

Supplementary files

Article information

Article type
Paper
Submitted
30 Jun 2023
Accepted
03 Aug 2023
First published
04 Sep 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 26247-26251

Development of a novel near-infrared molecule rotator for early diagnosis and visualization of viscosity changes in acute liver injury models

M. Fu, F. He, Z. Jiang, X. Chen, Z. Xie and J. Hu, RSC Adv., 2023, 13, 26247 DOI: 10.1039/D3RA04391F

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