Issue 31, 2023, Issue in Progress
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RSC Advances

The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis†

Veronica Ghini,ab   Michele Mannelli,c   Lara Massai,a   Andrea Geri,a   Stefano Zineddu,ab   Tania Gamberi, ORCID logo c   Luigi Messori ORCID logo *a  and  Paola Turano ORCID logo *abd  

* Corresponding authors

a Department of Chemistry “Ugo Schiff”, University of Florence, Sesto Fiorentino 50019, Italy
E-mail: luigi.messori@unifi.it, paola.turano@unifi.it

b Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino 50019, Italy

c Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence 50134, Italy

d Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), Sesto Fiorentino 50019, Italy

Abstract

NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the frame of the available mechanistic knowledge.

Graphical abstract: The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis

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Article information

DOI
https://doi.org/10.1039/D3RA04032A
Article type
Paper
Submitted
15 Jun 2023
Accepted
10 Jul 2023
First published
19 Jul 2023
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 21629-21632

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The effects of two cytotoxic gold(I) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis

V. Ghini, M. Mannelli, L. Massai, A. Geri, S. Zineddu, T. Gamberi, L. Messori and P. Turano, RSC Adv., 2023, 13, 21629 DOI: 10.1039/D3RA04032A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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