SCHEDULED MAINTENANCE
A general microwave synthesis of 4-oxo-3,4-dihydroquinazolin-2-yl propanoic acids and their diamide precursors from the corresponding substituted benzamide and succinic anhydride is described, using pinane as a sustainable solvent that favors the cyclization step. The conditions are some of the most simple and cost effective reported.
A. Richieu and P. Bertrand, RSC Adv., 2023, 13, 20646 DOI: 10.1039/D3RA03702A
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