Issue 38, 2023, Issue in Progress
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RSC Advances

A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity†

Shuhua Cao, ORCID logo *a   Anlin Wang,b   Kaoxue Li,a   Zhiteng Lin,a   Hongwei Yang,a   Xiaolei Zhang,a   Jianmei Qiua  and  Xishi Tai*a  

* Corresponding authors

a College of Chemistry, Chemical and Environmental Engineering, Weifang University, No. 5147 Dongfeng Street, Weifang, P. R. China
E-mail: shuhua@wfu.edu.cn, taixs@wfu.edu.cn

b Affiliated Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, P. R. China

Abstract

A novel tetranuclear Cu(II) complex (TNC) was successfully synthesized and characterized by X-ray single crystal diffraction. The interaction of the complex with calf thymus DNA (CT-DNA) has been studied by UV-vis absorption titration, fluorescence technology and molecular docking. The results indicated that TNC could bind to the DNA through an intercalative mode. The agarose gel electrophoresis experiment showed that TNC could cleave supercoiled plasmid DNA into linear DNA. The anticancer activity of TNC was tested on four cancer cell lines: MCF7, A549, 4T1 and HepG2. The results indicated that TNC shown significant activity against all of above cell lines.

Graphical abstract: A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity

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Article information

DOI
https://doi.org/10.1039/D3RA03624C
Article type
Paper
Submitted
30 May 2023
Accepted
29 Aug 2023
First published
04 Sep 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 26324-26329

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A novel tetranuclear Cu(II) complex for DNA-binding and in vitro anticancer activity

S. Cao, A. Wang, K. Li, Z. Lin, H. Yang, X. Zhang, J. Qiu and X. Tai, RSC Adv., 2023, 13, 26324 DOI: 10.1039/D3RA03624C

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