Folic acid–maltodextrin polymer coated magnetic graphene oxide as a NIR-responsive nano-drug delivery system for chemo-photothermal synergistic inhibition of tumor cells

Abstract

The combination of chemo-photothermal therapy with high efficiency and fewer side effects has a good application prospect in cancer treatment. It is of great significance to construct a nano-drug delivery system with cancer cell targeting, high drug loading and excellent photothermal conversion efficiency. Therefore, a novel nano-drug carrier MGO-MDP–FA was successfully constructed by coating folic acid-grafted maltodextrin polymers (MDP–FA) on the surface of Fe₃O₄-modified graphene oxide (MGO). The nano-drug carrier combined the cancer cell targeting of FA and the magnetic targeting of MGO. A large amount of anti-cancer drug doxorubicin (DOX) was loaded by π–π interaction, hydrogen bond interaction and hydrophobic interaction, with the maximum loading amount and loading capacity of 657.9 mg g⁻¹ and 39.68 wt%, respectively. Based on the excellent photothermal conversion efficiency of MGO, MGO-MDP–FA showed good thermal ablation effect of tumor cells in vitro under NIR irradiation. In addition, MGO-MDP–FA@DOX showed excellent chemo-photothermal synergistic tumor inhibition in vitro (tumor cell killing rate reached 80%). In conclusion, the novel nano-drug delivery system MGO-MDP–FA constructed in this paper provides a promising nano-platform for chemo-photothermal synergistic treatment of cancer.