Issue 29, 2023, Issue in Progress

Aptamer-based colorimetric and lateral flow assay approaches for the detection of toxic metal ions, thallium(i) and lead(ii)

Abstract

Thallium(I) and lead(II) ions are heavy metals and extremely toxic. These metals are environmental pollutants, posing a severe risk to the environment and human health. In this study, two approaches were examined using aptamer and nanomaterial-based conjugates for thallium and lead detection. The first approach utilized an in-solution adsorptionā€“desorption approach to develop colorimetric aptasensors for the detection of thallium(I) and lead(II) using gold or silver nanoparticles. The second approach was the development of lateral flow assays, and their performance was tested with thallium (limit of detection is 7.4 Ī¼M) and lead ion (limit of detection is 6.6 nM) spiked into real samples. The approaches assessed are rapid, inexpensive, and time efficient with the potential to become the basis for future biosensor devices.

Graphical abstract: Aptamer-based colorimetric and lateral flow assay approaches for the detection of toxic metal ions, thallium(i) and lead(ii)

Supplementary files

Article information

Article type
Paper
Submitted
13 Mar 2023
Accepted
14 Jun 2023
First published
04 Jul 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 20040-20049

Aptamer-based colorimetric and lateral flow assay approaches for the detection of toxic metal ions, thallium(I) and lead(II)

S. Srinivasan, V. Ranganathan, E. M. McConnell, B. M. Murari and M. C. DeRosa, RSC Adv., 2023, 13, 20040 DOI: 10.1039/D3RA01658G

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