Issue 20, 2023, Issue in Progress

Rugby ball-shaped magnetic microcapsule for tumor hyperthermia

Abstract

Magnetic hyperthermia (MH) induced by magnetic particles has been widely used to treat tumors. However, the limited heating conversion efficiency inspires the design and synthesis of versatile magnetic materials for enhancing the performance of MH. Herein, we developed rugby ball-shaped magnetic microcapsules as efficient MH agents. The size and shape of the microcapsules can be precisely controlled by adjusting the reaction time and temperature without surfactant assistance. Because of their high saturation magnetization and uniform size/morphology, the microcapsules showed excellent thermal conversion efficiency, with a specific absorption rate of 2391 W gāˆ’1. Additionally, we performed in vivo anti-tumor studies on mice and found that MH mediated by magnetic microcapsules effectively inhibited the advancement of hepatocellular carcinoma. The microcapsules' porous structure might allow them to efficiently load different therapeutic drugs and/or functional species. These beneficial properties make microcapsules ideal candidates for medical applications, particularly in disease therapy and tissue engineering.

Graphical abstract: Rugby ball-shaped magnetic microcapsule for tumor hyperthermia

Supplementary files

Article information

Article type
Paper
Submitted
25 Feb 2023
Accepted
26 Apr 2023
First published
09 May 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 13886-13891

Rugby ball-shaped magnetic microcapsule for tumor hyperthermia

S. Wang, N. Wen, B. Yan, X. Wang, Z. Cai, Y. Li and X. Liu, RSC Adv., 2023, 13, 13886 DOI: 10.1039/D3RA01294H

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