Conversion of 5-hydroxymethylfurfural to furan-2,5-dicarboxylic acid by a simple and metal-free catalytic system

Xue Wang; Xinyuan Guo; Xinmei Wang; Chi Li; Shanjun Wang; Han Li; Yan’an Gao; Yiying Li; Jinhui Wang; Huanjun Xu

doi:10.1039/D3RA01104F

Conversion of 5-hydroxymethylfurfural to furan-2,5-dicarboxylic acid by a simple and metal-free catalytic system†

Xue Wang,‡^a Xinyuan Guo,‡^b Xinmei Wang,‡^b Chi Li,^b Shanjun Wang,^b Han Li,^b Yan’an Gao,

^c Yiying Li,*^d Jinhui Wang*^ae and Huanjun Xu

*^be

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* Corresponding authors

^a Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China
E-mail: 15798946232@163.com

^b School of Science, Qiongtai Normal University, Haikou, China

^c Key Laboratory of Ministry of Education for Advanced Materials in Tropical, Island Resources, Hainan University, Haikou, China

^d College of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China

^e Key Laboratory of Child Cognition and Behavior Development of Hainan Province, Qiongtai Normal University, Haikou, China

Abstract

A simple and metal-free catalytic system composed of NaO^tBu/DMF and an O₂ balloon efficiently converted 5-hydroxymethylfurfural (5-HMF) to furan-2,5-dicarboxylic acid with an 80.85% yield. 5-HMF analogues and various types of alcohols were also transformed to their corresponding acids in satisfactory to excellent yield by this catalytic system.

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Conversion of 5-hydroxymethylfurfural to furan-2,5-dicarboxylic acid by a simple and metal-free catalytic system†

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Conversion of 5-hydroxymethylfurfural to furan-2,5-dicarboxylic acid by a simple and metal-free catalytic system

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