Issue 4, 2023, Issue in Progress

Synthesis of 2-iminothiazolidin-4-ones via copper-catalyzed [2 + 1 + 2] tandem annulation

Abstract

In this paper, an efficient synthesis of 2-iminothiazolidin-4-ones through a copper-catalyzed tandem annulation reaction of alkyl amines, isothiocyanates and diazo acetates is presented. Notable advantages of this [2 + 1 + 2] cyclization methodology include readily accessible starting materials, simple operation, mild reaction conditions, high yields, step-economy and diverse functional group tolerance. In addition, the reaction is applicable to the gram scale synthesis and the preparation of bioactive molecules.

Graphical abstract: Synthesis of 2-iminothiazolidin-4-ones via copper-catalyzed [2 + 1 + 2] tandem annulation

Supplementary files

Article information

Article type
Paper
Submitted
09 Dec 2022
Accepted
03 Jan 2023
First published
12 Jan 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 2220-2224

Synthesis of 2-iminothiazolidin-4-ones via copper-catalyzed [2 + 1 + 2] tandem annulation

M. Zhao, Y. Guo, Q. Wang, L. Liu, S. Zhang, W. Guo, L. Wu and F. G. Qiu, RSC Adv., 2023, 13, 2220 DOI: 10.1039/D2RA07872D

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