Palladium-catalyzed bicyclization of alkynyl aryl iodide with allenyl malonates

Ping-Xin Zhou; Yang Liu; Xueyan Du; Ning Liu; Kexin Li; Yuji Wu; Wang Feng; Xu Liu; Yingying Kong

doi:10.1039/D3QO01169K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Palladium-catalyzed bicyclization of alkynyl aryl iodide with allenyl malonates†

Ping-Xin Zhou,

*^a Yang Liu,^a Xueyan Du,^a Ning Liu,^a Kexin Li,^b Yuji Wu,^a Wang Feng,^a Xu Liu^b and Yingying Kong

*^a

Author affiliations

* Corresponding authors

^a School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, P. R. China
E-mail: zhoupingxin518@163.com, kongying@mail.ustc.edu.cn

^b School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, P. R. China

Abstract

A palladium-catalyzed highly regio- and stereoselective reaction of alkynyl aryl iodide with allenyl malonates was realized to afford a series of bicyclic compounds. The cascade process involves intramolecular carbopalladation of internal alkynes/intermolecular carbopalladation of allenes/cyclization. This new approach has good functional group compatibility and broad substrate scope.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D3QO01169K
Article type: Research Article
Submitted: 27 Jul 2023
Accepted: 13 Sep 2023
First published: 15 Sep 2023

Download Citation

Org. Chem. Front., 2023,10, 5451-5456

Permissions

Request permissions

Palladium-catalyzed bicyclization of alkynyl aryl iodide with allenyl malonates

P. Zhou, Y. Liu, X. Du, N. Liu, K. Li, Y. Wu, W. Feng, X. Liu and Y. Kong, Org. Chem. Front., 2023, 10, 5451 DOI: 10.1039/D3QO01169K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic Chemistry Frontiers

Palladium-catalyzed bicyclization of alkynyl aryl iodide with allenyl malonates†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Palladium-catalyzed bicyclization of alkynyl aryl iodide with allenyl malonates

Social activity

Search articles by author

Spotlight

Advertisements