Modular and stereoselective access to cis-diphosphinoalkenes

Abstract

Diphosphine ligands are highly popular but costly toolkit in organic chemistry. In this study, we disclose a modular approach for cis-diphosphinoalkenes and diphosphine ligand libraries. It experimentally features a concerted addition process, 1,4-O/S migration, and the construction of cis-only diphosphinoalkenes in a five-membered ring (C–P–O–P–C) manner. This modular assembly approach should contribute to the stereoselective establishment of a greater diphosphine ligand library of compounds, including DPPENs, DPPEs, and beyond.