Issue 15, 2023

Electrochemical oxidative radical cascade reactions for the synthesis of difluoromethylated benzoxazines

Abstract

Benzoxazines are important structures in pharmaceuticals and functional molecules. We herein describe an electrochemical oxidative strategy for the synthesis of benzoxazines without transition-metal catalysts and external oxidants. In a undivided cell, a series of olefinic amides can be transferred to difluoromethylated benzoxazines with up to 87% yield via oxydifluoromethylation with CF2HSO2Na as the difluoromethylation reagent.

Graphical abstract: Electrochemical oxidative radical cascade reactions for the synthesis of difluoromethylated benzoxazines

Supplementary files

Article information

Article type
Research Article
Submitted
16 May 2023
Accepted
25 Jun 2023
First published
28 Jun 2023

Org. Chem. Front., 2023,10, 3898-3902

Electrochemical oxidative radical cascade reactions for the synthesis of difluoromethylated benzoxazines

X. Chen, J. Jiang, X. Huang and W. He, Org. Chem. Front., 2023, 10, 3898 DOI: 10.1039/D3QO00731F

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