Here we report a [Cp*RhCl2]2 catalyzed three-component coupling cyclization of 2,3-allenoic acids and 2,3-allenols in the presence of Cu(OAc)2·H2O, affording furanone derivatives. The synthetic potential has been demonstrated. The mechanism has also been demonstrated by isotopic labeling experiments, unveiling unexpected reaction pathways.
![Graphical abstract: [Cp*RhCl2]2 catalyzed three-component coupling cyclization of 2,3-allenoic acids with 2,3-allenols in the presence of Cu(OAc)2·H2O](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D3QO00608E&imageInfo.ImageIdentifier.Year=2023)
J. Fan, X. Wu, C. Fu and S. Ma, Org. Chem. Front., 2023, 10, 3776 DOI: 10.1039/D3QO00608E
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