Synthesis of fluorinated allylic alcohols via photoinduced decarboxylative cross-coupling of α-fluoroacrylic acids and alcohols

Abstract

Herein, a practical and robust methodology for photoinduced decarboxylative and dehydrogenative cross-coupling is reported. A wide range of α-fluoroacrylic acids and structurally diverse alcohols were smoothly converted into the desired fluorinated allylic alcohols with high Z-stereoselectivity under mild conditions. These fluorinated allylic alcohols are versatile building blocks and important structural fragments in organic chemistry and pharmaceutical science. The feasibility of this synthetic strategy was fully demonstrated via a gram-scale reaction, further transformations, and late-stage modifications of bioactive molecules.