Issue 20, 2023

Deuteration of Pd-activated C(sp2)–H bonds in the solid state

Abstract

We report mechanochemically-induced deuteration of Pd-activated aromatic C(sp2)–H bonds at ambient temperature under solvent-free conditions. Deuterium was sourced from cysteine-d4 to obtain mono- or dideuterated products from various aromatic palladacycles. Next to good deuteration yields, based on time-resolved in situ Raman monitoring and DFT calculations, we present a detailed view of the reaction course in the solid state. The obtained knowledge could lead to the broader application of this methodology for the deuteration of organics.

Graphical abstract: Deuteration of Pd-activated C(sp2)–H bonds in the solid state

Supplementary files

Article information

Article type
Research Article
Submitted
19 May 2023
Accepted
29 Aug 2023
First published
31 Aug 2023
This article is Open Access
Creative Commons BY license

Inorg. Chem. Front., 2023,10, 6005-6014

Deuteration of Pd-activated C(sp2)–H bonds in the solid state

A. Bjelopetrović, D. Barišić, M. Juribašić Kulcsár, I. Halasz, M. Ćurić and S. Lukin, Inorg. Chem. Front., 2023, 10, 6005 DOI: 10.1039/D3QI00932G

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