A molybdenum-based nanoplatform with multienzyme mimicking capacities for oxidative stress-induced acute liver injury treatment

Abstract

Excessive level of ROS is one of the important causes of acute liver injury. Herein, we report a simple and economical method to synthesize MoS₂-PEG@BSA (MPB) nanosheets. Due to the valence state of the Mo element which participates in a redox reaction, the synthesized MPB nanosheets can scavenge different types of reactive oxygen species (ROS), including hydroxyl radicals and superoxide anions, and possess the ability to mimic catalase, superoxide dismutase, and glutathione peroxidase. Modified by bovine serum albumin, the biocompatibility of the MPB platform is greatly improved, and the acute liver injury caused by oxidative stress is relieved. Both in vitro and in vivo experiments confirmed the biocompatibility and efficiency in cell protection of MPB nanosheets. Moreover, MPB nanosheets exhibited a hepatoprotective effect, which reduces the number of apoptotic and necrotic tissues and inhibits the production of pro-inflammatory factors in disease models.