Issue 19, 2023

Quaternization-induced micellization of cationic glycopolymers

Abstract

Quaternization-induced self-assembly was developed as a strategy for the fabrication of sugar-containing nanoassemblies in water. The quaternization reaction of a series of block copolymers of PCL-b-P4VP (PCL, polycaprolactone block; P4VP, polyvinylpyridine block) and PMA-b-PDEAEMA (PMA, polymethacrylate block; PDEAEMA, poly(2-(diethylamino)ethyl methacrylate) block) with unprotected monosaccharides in water resulted in the glycol assemblies PCL-b-P4VP-G and PMA-b-PEAEMA-G, i.e., vesicles or micelles with a sugar wall. Furthermore, the binding ability of glycol assemblies against the representative lectin, concanavalin A, was investigated. Finally, we investigated the antibacterial activity and hemolysis ability of glycol micelles with various cationic amine moieties, and the mechanism for enhanced biocompatibility was explored.

Graphical abstract: Quaternization-induced micellization of cationic glycopolymers

Supplementary files

Article information

Article type
Paper
Submitted
30 Jan 2023
Accepted
17 Apr 2023
First published
18 Apr 2023

Polym. Chem., 2023,14, 2355-2362

Quaternization-induced micellization of cationic glycopolymers

J. Chen, Z. Zheng, D. Li, Z. Guan, X. Xu, C. Shang, Q. Zhang and G. Li, Polym. Chem., 2023, 14, 2355 DOI: 10.1039/D3PY00099K

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