Issue 45, 2023
From the journal:

Organic & Biomolecular Chemistry

Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase†

Yi Ling Goh,‡a   Shi Yang Preston Long,‡a   Mun Fei Eddy Wong,a   Lee Ling Tan,b   Elaine Tiong,b   Fong Tian Wongab  and  Zhennan Liu ORCID logo *a  

* Corresponding authors

a Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, Neuros #07-01, Singapore 138665, Republic of Singapore
E-mail: liu_zhennan@isce2.a-star.edu.sg

b Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos #07-01, Singapore 138673, Republic of Singapore

Abstract

Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF3 radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control.

Graphical abstract: Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase

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Article information

DOI
https://doi.org/10.1039/D3OB01779F
Article type
Communication
Submitted
13 Sep 2023
Accepted
31 Oct 2023
First published
01 Nov 2023

Org. Biomol. Chem., 2023,21, 8975-8978

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Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase

Y. L. Goh, S. Y. P. Long, M. F. E. Wong, L. L. Tan, E. Tiong, F. T. Wong and Z. Liu, Org. Biomol. Chem., 2023, 21, 8975 DOI: 10.1039/D3OB01779F

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