Complexing a DNA primer with an RNA template showed improved nonenzymatic template-directed primer extension, attributed to a shift in the DNA helicity from a B-type towards an A-type helix. A 2-fold (deoxyadenosine) and 4.5-fold (deoxycytidine) increase in conversion from initial DNA primer to a primer + 1 nucleotide product was observed.
S. J. Park, K. L. Callaghan and A. V. Ellis, Org. Biomol. Chem., 2023, 21, 6702 DOI: 10.1039/D3OB01179H
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