Issue 35, 2023

ReACT (redox-activated chemical tagging) chemistry enables direct derivatization and fluorescence detection of S-adenosyl-l-homocysteine (SAH)

Abstract

S-Adenosyl-L-homocysteine (SAH) is a universal byproduct and product inhibitor of the methyltransferase-catalyzed methylation reaction. Here based on ReACT (redox-activated chemical tagging) chemistry, direct derivatization and fluorescence measurement of SAH were achieved with features such as mild reaction conditions and simple operation.

Graphical abstract: ReACT (redox-activated chemical tagging) chemistry enables direct derivatization and fluorescence detection of S-adenosyl-l-homocysteine (SAH)

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2023
Accepted
12 Aug 2023
First published
14 Aug 2023

Org. Biomol. Chem., 2023,21, 7085-7089

ReACT (redox-activated chemical tagging) chemistry enables direct derivatization and fluorescence detection of S-adenosyl-L-homocysteine (SAH)

B. Lin, L. Xiang, Z. Yuan, Q. Hou, Y. Ruan and J. Zhang, Org. Biomol. Chem., 2023, 21, 7085 DOI: 10.1039/D3OB01073B

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