NHC-mediated photocatalytic deoxygenation of alcohols for the synthesis of internal alkynes via a Csp3–Csp coupling reaction

Xueji Ma; Liujie Wang; Xiaoqing Meng; Wenbo Li; Qin Wang; Yuke Gu; Lingna Qiu

doi:10.1039/D3OB01066J

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NHC-mediated photocatalytic deoxygenation of alcohols for the synthesis of internal alkynes via a Csp³–Csp coupling reaction†

Xueji Ma,

*^a Liujie Wang,

^a Xiaoqing Meng,^a Wenbo Li,^a Qin Wang,^a Yuke Gu^a and Lingna Qiu^a

Author affiliations

* Corresponding authors

^a School of Pharmacy, Key Laboratory of Nano-carbon Modified Film Technology Engineering of Henan Province, Xinxiang University, Xinxiang 453000, P. R. China
E-mail: xuejima@zju.edu.cn

Abstract

NHC-mediated deoxygenation of alcohols under photocatalytic conditions is described. The process provides various alkyl radicals, which can react with 1-bromoalkyne via Csp³–Csp coupling to afford internal alkynes in moderate to good yields. The method offers a new and convenient approach to synthesize internal alkynes.

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Article information

DOI: https://doi.org/10.1039/D3OB01066J
Article type: Communication
Submitted: 04 Jul 2023
Accepted: 31 Jul 2023
First published: 31 Jul 2023

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Org. Biomol. Chem., 2023,21, 6693-6696

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NHC-mediated photocatalytic deoxygenation of alcohols for the synthesis of internal alkynes via a Csp³–Csp coupling reaction

X. Ma, L. Wang, X. Meng, W. Li, Q. Wang, Y. Gu and L. Qiu, Org. Biomol. Chem., 2023, 21, 6693 DOI: 10.1039/D3OB01066J

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Organic & Biomolecular Chemistry