A rhodium-catalyzed synthesis of phenylacetate has been realized by direct C–H carboxymethylation of anilines bearing removable directing groups. The reaction occurred most efficiently in air, without any external base or oxidant. This methodology is expected to provide a facile and general access to various bioactive 2-amino aromatic acetic acid derivatives.
Q. Liu, Z. Ma, J. Zhang and X. Li, Org. Biomol. Chem., 2023, 21, 8320 DOI: 10.1039/D3OB00931A
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