An external oxidant free Ru(II)-catalyzed C–H activation followed by an intermolecular annulation between oximes and sulfoxonium ylides has been developed. This transformation proceeds smoothly with a broad range of substrates, affording a series of isoquinoline derivatives in moderate to good yields. This protocol was successfully applied to the synthesis of moxaverine.
D. Yang, H. Xu, X. Zhang, Y. Hu, D. Huang and H. Zhao, Org. Biomol. Chem., 2023, 21, 6750 DOI: 10.1039/D3OB00805C
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