Low-cost transition metal catalysed Negishi coupling: an update

Abstract

The Negishi coupling is a significant C–C bond-forming reaction to access synthetically valuable organic compounds. In recent years, researchers have developed sustainable first-row transition metal (Fe, Co, Ni and Cu) based complexes in place of the conventional Pd catalyst for this reaction. Several such low-cost metal-based catalysts showed high efficiency and potential application in natural product synthesis. This review focuses on the recent achievements in low-cost transition metal-based Negishi coupling reactions, covering reports from 2016.