A new two-step procedure for the synthesis of 1,4-dicarbonyls has been developed involving an efficient and clean Mo-catalyzed oxidative cleavage of cyclobutane-1,2-diols with DMSO, which is used as solvent and oxidant. The required starting glycols were prepared by nucleophilic additions of organolithiums and Grignard reagents to easily available 2-hydroxycyclobutanones.
S. Gómez-Gil, R. Rubio-Presa, R. Hernández-Ruiz, S. Suárez-Pantiga, M. R. Pedrosa and R. Sanz, Org. Biomol. Chem., 2023, 21, 4185 DOI: 10.1039/D3OB00436H
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